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Yevgenia Kozorovitskiy

Soretta and Henry Shapiro Research Professor of Molecular Biology, Associate Professor

PhD, Princeton


Regions(s): Systems Neuroscience; Brain and Behavior; Developmental Neuroscience; Cellular and Molecular Neuroscience

Research interest(s): Synaptic and Circuit Development in the Basal Ganglia

Research Summary

The Kozorovitskiy lab focuses on two broad, inter-related themes: decoding neuromodulation and neural circuit design principles. We seek to address the following questions:

  • What activity-dependent rules govern the design of neural circuits and synapses in early life?
  • How are these rules updated by experience and broken in disease?
  • What is the function of neuromodulation during development and in behavior?   
  • How do multiplexed neuromodulatory systems operate?

We investigate these questions primarily, but not exclusively, in the basal ganglia, a phylogenetically ancient region of the brain essential for complex, goal directed motor actions and reward-based behavior. One of our primary current interests is the influence of neurotransmitters, such as glutamate, GABA and dopamine, on synaptic development and neural circuit integration. To address these questions, we rely on 2-photon imaging and 2-photon neurotransmitter photorelease, whole-cell electrophysiology, opto- and pharmacogenetics, neuroanatomy, computational and behavioral analyses. We develop new rapid 3D fluorescence imaging modalities to facilitate neurobiological discoveries. 

Selected Publications

Selected Honors/Awards

  • 2019      NSF CAREER Award
  • 2016      Searle Scholar Award, Kinship Foundation
  • 2016      Sloan Research Fellowship, Alfred P. Sloan Foundation
  • 2015      Cornew Innovation Award, Chemistry of Life Processes Institute
  • 2015      Beckman Young Investigator Award, Arnold & Mabel Beckman Foundation
  • 2015      Rita Allen Scholar Award, Rita Allen Foundation
  • 2015      Whitehall Foundation Grant
  • 2015      Early Career Investigators Innovation Award, William N. and Bernice E. Bumpus Foundation
  • 2015      NARSAD Young Investigator Grant, Brain and Behavior Research Foundation
  • 2014      Searle Leadership Fund Award, Northwestern University
  • 2013      Anuradha Rao Memorial Award, Society for Neuroscience
  • 2008      William F. Milton Fund Award, Harvard Medical School
  • 2007      Junior Fellowship, Harvard University Society of Fellows
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