Mark Segraves
Professor Emeritus
Specializations
Regions(s): Systems Neuroscience; Brain and Behavior
Research interest(s): Systems and cognitive neuroscience; sensorimotor integration; selection and control of eye movements in primates
Research Summary
Systems and cognitive neuroscience; sensorimotor integration; selection and control of eye movements in primates
The generation of eye movements is an important function of the brain's control systems. My laboratory uses the eye movement system as a model for how the brain of primates, including man, controls a variety of movements. Our work focuses upon areas of the rhesus monkey's prefrontal cortex and midbrain that help to control eye movements. We use behavioral and neurophysiological techniques in awake, behaving monkeys to allow us to examine the processing of information taking place within these areas, and to enable us to understand the role these neural structures perform in the complex network of connections that make up the oculomotor system.
Selected Publications
- Fernandes HL, Stevenson IH, Phillips AN, Segraves MA, Kording KP (2013) Saliency and Saccade Encoding in the Frontal Eye Field During Natural Scene Search. Cereb Cortex.
- Campos M, Segraves MA. (2011) Signal multiplexing in neural circuits – the superior colliculus deserves a new look. Front Integr Neurosci, 5:5.
- Ratcliff R, Hasegawa YT, Hasegawa RP, Childers R, Smith PL, Segraves MA. (2011) Inhibition in superior colliculus neurons in a brightness discrimination task. Neural Comput, 23:1790-1820.
- Phillips AN, Segraves MA. (2010). Predictive Activity in Macaque Frontal Eye Field Neurons During Natural Scene Searching. J Neurophysiol, Dec 16.
- Hasegawa RP, Hasegawa YT, Segraves MA. (2009). Neural mind reading of multi-dimensional decisions by monkey mid-brain activity. Neural Net, Nov;22(9):1247-56.
- Ratcliff R, Hasegawa YT, Hasegawa RP, Smith PL, Segraves MA. (2007). Dual diffusion model for single-cell recording data from the superior colliculus in a brightness-discrimination task. J Neurophysiol, 97(2):1756-74.
- Hasegawa RP, Hasegawa YT, Segraves MA. (2006). Single trial-based prediction of a go/no-go decision in monkey superior colliculus. Neural Net, 19(8):1223-32.
- Farrell S, Ratcliff R, Cherian A, Segraves MA. (2006). Modeling unidimensional categorization in monkeys. Learn Behav, 34(1):86-101.
- Campos M, Cherian A, Segraves MA. (2006). Effects of eye position upon activity of neurons in macaque superior colliculus. J Neurophysiol, 95(1):505-26.
- Ratcliff R, Cherian A, Segraves MA. (2003). A comparison of macaque behavior and superior colliculus neuronal activity to predictions from models of two-choice decisions. J Neurophysiol, 90:1392-1407.
- Helminski JO, Segraves MA. (2003). Macaque frontal eye field input tosaccade-related neurons in the superior colliculus. J Neurophysiol, 90:1046-1062.
Selected Honors/Awards
- 1989-94 National Institutes of Health F.I.R.S.T. Award
- 1989-93 Alfred P. Sloan Research Fellowship in Neuroscience
- 1982 Postdoctoral Fellowship, Individual National Research Service Award, EY05627- 01. Award declined following receipt of NIH Intramural Staff Fellowship
- 1981-82 Postdoctoral Fellowship, Swiss National Science Foundation
- 1980, 81 Grass Foundation Summer Fellowships
- 1976-80 Predoctoral Fellow supported by NIH training grant to Department of Anatomy, University of Pennsylvania
- 1973 Phi Sigma Society (Biology)