Valerie Kilman
Director of Undergraduate Studies in Neurobiology / Professor of Instruction in Neurobiology
- v-kilman@northwestern.edu
- Website
- Hogan 2-162
Specializations
Regions(s): Cellular and Molecular Neuroscience; Systems Neuroscience; Developmental Neuroscience; Brain and Behavior; Neurogenetics
Research interest(s): neural networks underlying behavior, circadian rhythms and sleep; neural pattern generation, homeostatic plasticity
Teaching
Current
- NEUROSCI 355-0 Neurogenetics of Behavior Laboratory
- NEUROSCI 360-0 Neuroscience of Brain Disorders
- NEUROSCI 390-0-27 Neuroscience in the News
- NEUROSCI 398-0 Senior Thesis Seminar
Research Summary
I am interested in the role of project-based practical laboratory experience and writing in enhancing learning. I teach the senior thesis seminar in the neuroscience major as well as a project-based laboratory course. Since joining the teaching track in 2015, I have occasionally served as the faculty mentor for undergraduates working on summer grant-funded projects. This work involved using the fruit fly Drosophila to study learned helplessness, a laboratory paradigm that models certain aspects of depression.
More generally, I am interested in the genetic and circuit underpinnings of behavior and disease. The fruit fly Drosophila is an excellent model system in which to pose questions about conserved basic biological processes such as these. Some of my own projects have included the role of a neuromodulator in biological clock resetting, the development of circadian clocks, and the role of the circadian clock in neurodegenerative disease.
Selected Publications
- Kilman VL and Allada R. (2009). Genetic analysis of ectopic circadian clock induction in Drosophila. J Biol Rhythms, 24: 368-378.
- Kilman VL, Zhang L, Meissner RA, Burg E, Allada R. (2009). Perturbing dynamin reveals potent effects on the Drosophila circadian clock. PLoS ONE, 4(4): e5235.
- Zhao J, Kilman VL, Keegan KP, Peng Y, Emery P, Rosbash M, Allada R, (2003) Drosophila clock can generate ectopic circadian clocks, Cell., 113(6):755-66. doi: 10.1016/s0092-8674(03)00400-8.PMID: 12809 606
- Kilman V, van Rossum MC, Turrigiano GG.J (2002). Activity deprivation
reduces miniature IPSC amplitude by decreasing the number of
postsynaptic GABA(A) receptors clustered at neocortical synapses. J Neurosci, 22(4):1328-37. doi: 10.1523/JNEUROSCI.22-04-01328.2002.PMID: 11850460 - Kilman V, Fénelon VS, Richards KS, Thirumalai V, Meyrand P, Marder E (1999).
Sequential developmental acquisition of cotransmitters in identified
sensory neurons of the stomatogastric nervous system of the lobsters,
Homarus americanus and Homarus gammarus. J Comp Neurol, 408(3):318-34. doi: 10.1002/(sici)1096-9861(19990607)408:3<318::aid-cne2>3.0.co;2-s.PMID: 10340509