DEPARTMENT OF NEUROBIOLOGY

Specializations

Regions(s): Neurogenetics; Brain and Behavior

Research interest(s): Mouse Behavioral Genetics, particularly Circadian Rhythms, Sleep, Arousal, Affect

Research Summary

My research uses a variety of genetic approaches to understanding the links between circadian (daily) rhythms, sleep, and mammalian health and physiology.

Selected Publications

• Voigt RM, Forsyth CB, Green SJ, Mutlu E, Engen P, Vitaterna MH, Turek FW, Keshavarzian A. (2014). Circadian disorganization alters intestinal microbiota. PLoS One, 9(5):e97500. PMID: 24848969
• Zhou L, Bryant CD, Loudon A, Palmer AA, Vitaterna MH, Turek FW. (2014). The circadian clock gene Csnk1e regulates rapid eye movement sleep amount, and nonrapid eye movement sleep architecture in mice. Sleep, 37(4):785-93, 793A-793C. PMID: 24744456
• Summa KC, Vitaterna MH, Turek FW. (2012). Environmental perturbation of the circadian clock disrupts pregnancy in the mouse. PLoS One, 7(5):e37668. PMID: 22649550
• Arble DM, Vitaterna MH, Turek FW. (2011). Rhythmic Leptin Is Required for Weight Gain from Circadian Desynchronized Feeding in the Mouse. PLoS One, 6(9):e25079. PMID: 21949859
• Yang HS, Shimomura K, Vitaterna MH, Turek FW. (2012). High-resolution mapping of a novel genetic locus regulating voluntary physical activity in mice. Genes Brain Behav, 11(1):113-24. PMID: 21978078
• Millstein J, Winrow CJ, Kasarskis A, Owens JR, Zhou L, Summa KC, Fitzpatrick K, Zhang B, Vitaterna MH, Schadt EE, Renger JJ, Turek FW. (2011). Identification of causal genes, networks, and transcriptional regulators of REM sleep and wake. Sleep, 34(11):1469-77. PMID: 22043117
• Winrow CJ, Williams DL, Kasarskis A, Millstein J, Laposky AD, Yang HS, Mrazek K, Zhou L, Owens JR, Radzicki D, Preuss F, Schadt EE, Shimomura K, Vitaterna MH, Zhang C, Koblan KS, Renger JJ, Turek FW. (2009). Uncovering the genetic landscape for multiple sleep-wake traits. PLoS One, 4(4):e5161. PMID: 19360106
• Vitaterna MH, Pinto LH, Takahashi JS. (2006). Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice. Trends Neurosci, 29(4):233-40. PMID: 16519954
• Vitaterna MH, Ko CH, Chang AM, Buhr ED, Fruechte EM, Schook A, Antoch MP, Turek FW, Takahashi JS. (2006). The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude. Proc Natl Acad Sci U S A,103(24):9327-32. PMID: 16754844
• Vitaterna MH, Selby CP, Todo T, Niwa H, Thompson C, Fruechte EM, Hitomi K, Thresher RJ, Ishikawa T, Miyazaki J, Takahashi JS, Sancar A. (1999). Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A, 96(21):12114-9. PMID: 10518585
• Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS. (1994). Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science, 264(5159):719-25. PMID: 8171325

Centers/Institutes

• Executive Director, Center for Sleep and Circadian Biology